Test Highlights:

  • DNA samples can be collected easily at home using buccal (cheek) swabs.
  • Dogs can be DNA tested at ANY age using the buccal swabs.
  • DNA results are emailed within 5 business days of receipt of the samples
  • Test fee is $58 (US) per canine, multi-test discounts may apply

Collie Eye Anomaly (CEA)

Collie Eye Anomaly (CEA), also known as Choroidal Hypoplasia (CH-Choroidal Hypoplasia), is inherited as an autosomal recessive disease. The retina gets its blood supply and nutrients from the choroid. In affected dogs, this layer of tissue under the retina does not develop properly, and is thinner than normal. Predicting the severity of an affected puppy is difficult as it can vary greatly, even between affected puppies in the same litter. Severely affected dogs may experience vision loss and retinal detachment.

DDC Veterinary is offering DNA testing for CEA (NHEJ1). Breeders now have an accurate, convenient, and affordable tool to help them avoid producing CEA-affected offspring, and significantly reduce the gene-frequency in future generations.

This mutation can affect the following breeds:

Aussiedoodle

Australian Shepherd

Bearded Collie

Border Collie

Boykin Spaniel

Collie

English Shepherd

Hokkaido

Lancashire Heeler

Longhaired Whippet

Miniature Australian Shepherd

Nova Scotia Duck Tolling Retriever

Rough Collie

Shetland Sheepdog

Silken Windhound

Smooth Collie

Toy Australian Shepherd

There are three possible genotypes reported:

  1. CLEAR (those having two (2) copies of the normal allele and appear to be normal)
  2. CARRIER (those having one (1) copy of the normal allele and 1 copy of the CEA mutation but appear to be normal)
  3. AFFECTED (those having two (2) copies of the CEA mutation and can develop eye and optic nerve malformations, retinal detachment, and blindness over time)

Although carriers will not show clinical signs of the disease, it is important to note, if used for breeding, carriers are likely to pass on the mutation 50% of the time. Therefore a carrier x carrier mating will likely result in producing affected pups in about 25% of the offspring.

Results are based upon the specific NHEJ1 mutation. Clear results for CEA only pertain to the NHEJ1 mutation tested.This test does not detect whether or not a dog has any other form of eye diseases.

Have questions? Check our Canine DNA FAQ >>

For more information about how these test results can be used for registration, contact the Orthopedic Foundation for Animals (OFA).