Hereditary Nasal Parakeratosis (HNPK)

Test Highlights:

  • DNA samples can be collected easily at home using buccal (cheek) swabs.
  • Dogs can be DNA tested at ANY age using the buccal swabs.
  • DNA results are emailed within 5 business days of receipt of the samples
  • Test fee is $58 (US) per canine, multi-test discounts may apply

Hereditary Nasal Parakeratosis (HNPK) is an inherited autosomal recessive disorder. Affected dogs begin showing clinical signs around six to twelve months of age. They develop dry, rough crusts on the tip of the nose. In extreme cases, the dog’s nose will crack causing severe discomfort. Lesions can occur on the area around the nose. The noses of these affected dogs are prone to bacterial infections and can lose pigment over time. This disorder may be treated with veterinary consultation and topical therapy.

DDC Veterinary is offering DNA Testing for Hereditary Nasal Parakeratosis. Labrador Breeders have an accurate, convenient, and affordable tool to help them avoid producing HNPK affected offspring and significantly reduce the gene frequency in future generations.


There are 3 possible genotypes reported for Hereditary Nasal Parakeratosis:

  • CLEAR (those having 2 copies of the normal allele and appear to be normal).
  • CARRIER (those having 1 copy of the normal allele and 1 copy of the mutation and most appear to be normal).
  • AT RISK (those having 2 copies of the mutation and will likely show clinical signs.)

It is important to note, although carriers will not show clinical signs for the disease, if used for breeding, they will likely pass on the mutation 50% of the time, therefore a carrier x carrier mating will likely result in producing affected pups in about 25% of the offspring.


Canine DNA frequently asked questions


For more information about how these test results can be used for registration, contact the Orthopedic Foundation for Animals (OFA) or the Canine Health Information Center (CHIC).